COReS Seminar Series – Emerging trends in systematic reviews for 3R principles

A systematic review uses a transparent and structured approach to identify and evaluate results of existing studies on a research question. Systematic reviews are a powerful tool to assess the accumulating evidence in biomedical research. As such, systematic reviews can help us address specific research questions and be used to directly inform the classical 3Rs principles in animal research – Replacement, Reduction, Refinement.  

Systematic reviews themselves are considered animal-free innovations as they can lead to new results and scientific insights without performing additional animal studies. They can help prevent unnecessary duplication by comprehensively summarizing what has been done already as well as help us to choose the optimal animal model for our research questions. Systematic reviews can help us make evidence-informed decisions for animal research, including informing sample size calculations and refining experiments conduct, as well as supporting translational decisions. If you are interested to learn more about evidence synthesis, visit our ‘About Synthesis’ section.  

The conduct of systematic reviews to support animal research is increasing in popularity and advances and techniques are developing rapidly. This seminar series showcases emerging trends on systematic reviews of animal studies. During each session, an expert guest speaker will provide insights into their work in this space, showcasing specific tools, approaches and resources and sharing cutting edge ideas.   

“Latest Developments on the Reporting Guideline PRISMA-Preclinical” – Dr Manoj Lalu

In the 1st session, Dr Manoj M. Lalu will tell us more about PRISMA-Preclinical. Why do we need a PRISMA guideline specific for systematic reviews in animal research? How was it developed? And what will be the next steps?

Short Bio: Manoj M. Lalu, MD, PhD, FRCPC is an anesthesiologist and researcher focused on moving basic science discoveries to early phase clinical trials. He co-leads the Blueprint Translational Research Group at the Ottawa Hospital Research Institute. The group adopts a variety of approaches (systematic reviews/meta-research, qualitative interview studies, early economic analyses, preclinical lab studies) to better understand and improve the ‘translational’ process.  

Sign up to the session on 28th March at 5pm CET here: https://us06web.zoom.us/meeting/register/tZUkc-ihrDkvG9ZG0asLPUJ8PDQIo1Jsj_G-#/registration